An alergic reaction won't occur on the 1st exposure to a substance
The 1st exposure allows the body to create antibodies and memory lymphocyte cells for the antigen
However, drugs often contain many different substances, including dyes, which could cause allergic reactions. This can cause an allergic reaction on the 1st administration of a drug
Prognosis
Medical attention should be sought IMMEDIATELY if an allergic reaction is suspected
Epidemiology
Most patients who believe they are allergic to aspirin are actually suffering froma drug intolerance, and NOT a drug allergy
See also
Drug intolerance, which is a milder, non-immune-mediated reaction, that doesn't depend on prior exposure
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